Autoinducer-2 Signaling: Modulates Cell-Cell Quorum Sensing in Oral Biofilm
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چکیده
منابع مشابه
Inhibitors of Autoinducer-2 Quorum Sensing and Their Effect on Bacterial Biofilm Formation
Title of Document: INHIBITORS OF AUTOINDUCER-2 QUORUM SENSING AND THEIR EFFECT ON BACTERIAL BIOFILM FORMATION Rebecca Melissa Lennen, Master of Science, 2007 Directed by: Dr. William Bentley, Professor Department of Bioengineering Bacteria utilize small signaling molecules, or autoinducers, to regulate their gene expression in tandem by a process termed quorum sensing. The gene encoding the syn...
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The autoinducer-2 (AI-2) quorum-sensing system has been linked to diverse phenotypes and regulatory changes in pathogenic bacteria. In the present study, we performed a molecular and biochemical characterization of the AI-2 system in Yersinia pestis, the causative agent of plague. In strain CO92, the AI-2 signal is produced in a luxS-dependent manner, reaching maximal levels of 2.5 μM in the la...
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Magnetic 'nanofactories', for localized manufacture and signal-guided delivery of small molecules to targeted cell surfaces, are demonstrated. They recruit nearby raw materials for synthesis, employ magnetic mobility for capture and localization of target cells, and deliver molecules to cells triggering their native phenotypic response, but with user-specified control. Our nanofactories, which ...
متن کاملPleiotropic role of quorum-sensing autoinducer 2 in Photorhabdus luminescens.
Bacterial virulence is an integrative process that may involve quorum sensing. In this work, we compared by global expression profiling the wild-type entomopathogenic Photorhabdus luminescens subsp. laumondii TT01 to a luxS-deficient mutant unable to synthesize the type 2 quorum-sensing inducer AI-2. AI-2 was shown to regulate more than 300 targets involved in most compartments and metabolic pa...
متن کاملA Host-Produced Autoinducer-2 Mimic Activates Bacterial Quorum Sensing.
Host-microbial symbioses are vital to health; nonetheless, little is known about the role crosskingdom signaling plays in these relationships. In a process called quorum sensing, bacteria communicate with one another using extracellular signal molecules called autoinducers. One autoinducer, AI-2, is proposed to promote interspecies bacterial communication, including in the mammalian gut. We sho...
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ژورنال
عنوان ژورنال: Dentistry
سال: 2016
ISSN: 2161-1122
DOI: 10.4172/2161-1122.1000e116